Beth Israel Deaconess Medical Center MARGRET & H. A. REY
for Nonlinear Dynamics in Medicine
Harvard Medical School

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ECG Wave-Maven

Center for Dynamical Biomarkers

Ary L. Goldberger, M.D., is the Director of the Rey Laboratory and Professor of Medicine at the Harvard Medical School. He is the Program Director of the Research Resource for Complex Physiologic Signals ( funded by the National Institute of Biomedical Imaging and Bioengineering and National Institute of General Medical Sciences of the National Institutes of Health. He is also a core faculty member of the Wyss Institute for Biologically Inspired Engineering at Harvard University. (Please note: Dr. Goldberger is on the right of the photo.)

Dr. Goldberger has a long-standing interest in electrocardiography and non-invasive electrophysiology and is the author of two standard textbooks on ECG analysis (Goldberger AL. Clinical Electrocardiography: A Simplified Approach, 6th edition, St. Louis, Mosby, 1999, and Goldberger AL. Myocardial Infarction: Electrocardiographic Differential Diagnosis, 4th edition, Mosby-Year Book, 1991). Both books have been translated into a number of languages. Dr. Goldberger and his colleagues at the Beth Israel Deaconess Medical Center have also created ECG Wave-Maven (http://ecg.bidmc.har, an open-access program for medical students and clinicians.

Dr. Goldberger and his colleagues have helped pioneer the application of fractals to physiology and medicine over the past two decades (see Lancet 347:1312-14, 1996). They published the first papers describing the fractal nature of normal cardiac electrophysiology and on fractal mechanisms in a variety of other physiological systems, as well as in the analysis of coding vs. noncoding DNA nucleotide sequences (Nature 1992:356:168-170; Biophys J 1993:65:2673-2679; Biophys J 1994;49:1685 -1689; Phys Rev E 1994;49:1685-1689). Current work focuses on the breakdown of long-range (fractal) correlations and loss of nonlinear complexity that accompanies aging and a wide range of disease processes (Proc Natl Acad Sci USA 2002;99[suppl 1]:2466-2472.; Phys Rev Lett 2002;89:068102.). Dr. Goldberger's work on fractal physiology and nonlinear dynamics in medicine is featured in the widely-acclaimed book by James Gleick, entitled Chaos: Making a New Science, Viking, 1987.