News Physiol Sci. 1991 Apr;6:87-91. Is the normal heartbeat chaotic or homeostatic? Goldberger AL. Harvard Medical School, Boston, MA 02215. Limits to the usefulness of homeostasis as a guiding physiological principle are revealed by new mechanisms derived from study of nonlinear systems that generate a type of variability called chaos. Loss of complex physiological variability may occur in certain pathological conditions including heart rate dynamics before sudden death and with aging. Publication Types: Review Review, Tutorial PMID: 11537649 [PubMed - indexed for MEDLINE]