Beth Israel Deaconess Medical Center MARGRET & H. A. REY
for Nonlinear Dynamics in Medicine
Harvard Medical School

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Highly-Cited Articles

(Data source: Science Citation Index; Updated: August, 2011)

  1. Mosaic organization of DNA nucleotides.
    Peng CK, Buldyrev SV, Havlin S, Simons M, Stanley HE, Goldberger AL.
    Phys Rev E 1994;49:1685-1689. Citations: 1124
  2. Quantification of scaling exponents and crossover phenomena in nonstationary heartbeat time series.
    Peng CK, Havlin S, Stanley HE, Goldberger AL.
    Chaos 1995;5:82-87. Citations: 995
  3. Long-range correlations in nucleotide sequences.
    Peng CK, Buldyrev SV, Goldberger AL, Havlin S, Sciortino F, Simons M, Stanley HE.
    Nature 1992;356:168-170. Citations: 714
  4. PhysioBank, PhysioToolkit, and PhysioNet: components of a new research resource.
    Goldberger AL, Amaral LA, Glass L, Hausdorff JM, Ivanov PC, Mark RG, Mietus JE, Moody GB, Peng CK, Stanley HE.
    Circulation 2000;101:E215. Citations: 677
  5. Multifractality in human heartbeat dynamics.
    Ivanov PCh, Amaral LAN, Goldberger AL, Havlin S, Rosenblum MG, Struzik Z, Stanley HE.
    Nature 1999;399:461-465. Citations: 539
  6. Long-range anticorrelations and non-Gaussian behavior of the heartbeat.
    Peng CK, Mietus J, Hausdorff JM, Havlin S, Stanley HE, Goldberger AL.
    Phys Rev Lett 1993;70:1343-1346. Citations: 485
  7. Physiological time-series analysis: What does regularity quantify?
    Pincus SM, Goldberger AL.
    Am J Physiol 1994;266:H1643-H1656. Citations: 433
  8. Fractal dynamics in physiology: Alterations with disease and aging
    Goldberger AL, Amaral LAN, Hausdorff JM, Ivanov PC, Peng CK, Stanley HE
    PNAS USA 2002;99:2466-2472. Citations: 420
  9. Spectral characteristics of heart rate variability before and during postural tilt - Relations to aging and risk of syncope.
    Lipsitz LA, Mietus JE, Moody GB, Goldberger AL.
    Circulation 1990;81:1803-1810. Citations: 376
  10. Statistical properties of the volatility of price fluctuations.
    Liu Y, Gopikrishnan P, Cizeau P, Meyer M, Peng CK, Stanley HE.
    Phys Rev E 1999;60:1390-1400. Citations: 327
  11. Long-range correlation properties of coding and noncoding DNA sequences: GenBank analysis.
    Buldyrev SV, Goldberger AL, Havlin S, Mantegna RN, Matsa ME, Peng CK, Simons M, Stanley HE.
    Phys Rev E 1995;51:5084-5091. Citations: 306
  12. Loss of complexity and aging. Potential applications of fractals and chaos theory to senescence.
    Lipsitz LA, Goldberger AL.
    JAMA. 1992;267:1806-1809. Citations: 291
  13. Non-linear dynamics for clinicians: chaos theory, fractals, and complexity at the bedside.
    Goldberger AL.
    Lancet. 1996;347:1312-1314. Citations: 269
  14. Scaling behaviour of heartbeat intervals obtained by wavelet-based time series analysis.
    Ivanov PCh, Rosenblum MG, Peng CK, Mietus J, Havlin S, Stanley HE, Goldberger AL.
    Nature 1996;383:323-327. Citations: 260
  15. Aging and the complexity of cardiovascular dynamics.
    Kaplan DT, Furman MI, Pincus SM, Ryan SM, Lipsitz LA, Goldberger AL.
    Biophys J 1991;59:945-949. Citations: 232
  16. Is walking a random walk? Evidence for long-range correlations in stride interval of human gait.
    Hausdorff JM, Peng CK, Ladin Z, Wei JY, Goldberger AL.
    J Appl Physiol 1995;78:349-358. Citations: 230
  17. Fractal correlation properties of R-R interval dynamics and mortality in patients with depressed left ventricular function after an acute myocardial infarction.
    Huikuri HV, Makikallio TH, Peng CK, Goldberger AL, Hintze U, Moller M.
    Circulation 2000;101:47-53. Citations: 225
  18. Predicting survival in heart failure case and control subjects by use of fully automated methods for deriving nonlinear and conventional indices of heart rate dynamics.
    Ho KKL, Moody GB, Peng CK, Mietus JE, Larson MG, Levy D, Goldberger AL.
    Circulation 1997;96:842-848. Citations: 208
  19. Altered fractal dynamics of gait: reduced stride interval correlations with aging and Huntington's disease.
    Hausdorff JM, Mitchell SL, Firtion R, Peng CK, Cudkowicz ME, Wei JY, Goldberger AL.
    J Appl Physiol 1997;82:262-269. Citations: 205
  20. Age-related alterations in the fractal scaling of cardiac interbeat interval dynamics.
    Iyengar N, Peng CK, Morin R, Goldberger AL, Lipsitz LA.
    Am J Physiol 1996;271:R1078-R1084. Citations: 199
  21. Multiscale entropy analysis of complex physiologic time series
    Costa M, Goldberger AL, Peng CK
    Phys Rev Lett 2002;89:068102. Citations: 184
  22. Gait variability and basal ganglia disorders: Stride-to-stride variations of gait cycle timing in Parkinson's disease and Huntington's disease
    Hausdorff JM, Cudkowicz ME, Firtion R, Wei JY, Goldberger AL.
    Movement Disorders, 13:428-437 May 1998. Citations: 179
  23. Magnitude and sign correlations in heartbeat fluctuations.
    Ashkenazy Y, Ivanov PCh, Havlin S, Peng CK, Goldberger AL, Stanley HE.
    Phys Rev Lett 2001;86:1900-1903. Citations: 179
  24. Linguistic features of noncoding DNA sequences.
    Mantegna RN, Buldyrev SV, Goldberger AL, Havlin S, Peng CK, Simons M, Stanley HE.
    Phys Lett Rev 1994;73:3169-3172. Citations: 175
  25. Gender-related and age-related differences in heart rate dynamics: are women more complex than men?
    Ryan SM, Goldberger AL, Pincus SM, Mietus JE, Lipsitz LA.
    J Am Coll Cardiol 1994;24:1700-1707. Citations: 171
  26. Fractal dynamics of human gait: Stability of long-range correlations in stride interval fluctuations
    Hausdorff JM, Purdon PL, Peng CK, Ladin Z, Wei JY, Goldberger AL.
    J Appl Physiol 1996;80:1448-1457. Citations: 168
  27. Cardiac interbeat interval dynamics from childhood to senescence: comparison of conventional and new measures based on fractals and chaos theory.
    Pikkujämsä SM, Mäkikallio TH, Sourander LB, Räihä IJ, Puukka P, Skyttä J, Peng CK, Goldberger AL, Huikuri HV.
    Circulation 1999;100:393-399. Citations: 164
  28. Correlations in economic time series
    Liu Y, Cizeau P, Meyer M, Peng CK, Stanley HE.
    Physica A 1997;245:437-440. Citations: 141
  29. From 1/f noise to multifractal cascades in heartbeat dynamics.
    Ivanov PC, Nunes Amaral LA, Goldberger AL, Havlin S, Rosenblum MG, Stanley HE, Struzik ZR.
    Chaos. 2001 Sep;11(3):641-652. Citations: 134
  30. Statistical physics and physiology: Monofractal and multifractal approaches
    Stanley He, Amaral LA, Goldberger AL, Havlin,S, Ivanov PCh, Peng CK.
    Physica A. 1999;270:309-24. Citations: 131
  31. Finite size effects on longrange correlations: implications for analyzing DNA sequences
    Peng CK, Buldyrev SV, Goldberger AL, Havlin S, Simons M, Stanley HE.
    Phys Rev E 1993;47:3730-3733. Citations: 130
  32. Multiscale entropy analysis of biological signals.
    Costa M, Goldberger AL, Peng C-K.
    Phys Rev E 2005;71:021906. Citations: 127 View the .
  33. What is physiologic complexity and how does it change with aging and disease?
    Goldberger AL, Peng CK, Lipsitz LA.
    Neurobiol Aging. 2002 Jan-Feb;23(1):23-6. Citations: 123
  34. Behavioral-independence features of complex heartbeat dynamics
    Amaral LAN, Ivanov PCh, Aoyagi N, Hidaka I, Tomono S, Goldberger AL, Stanley HE, Yamamoto Y.
    Phys Rev Lett 2001;86:6026-6029. Citations: 121
  35. Fractal analysis of heart rate dynamics as a predictor of mortality in patients with depressed left ventricular function after acute myocardial infarction
    Makikallio TH, Hoiber S, Kober L, Torp-Pedersen C, Peng CK, Goldberger AL, Huikuri HV
    Am J Cardiol 1999;83:836-839. Citations: 120
  36. Generalized Levy walk model for DNA nucleotide sequences.
    Buldyrev SV, Goldberger AL, Havlin S, Peng CK, Simons M, Stanley HE.
    Phys Rev E 1993;47:4514-4523. Citations: 112
  37. Sleep-wake differences in scaling behavior of the human heartbeat: Analysis of terrestrial and long-term space flight data
    Ivanov PCh, Bunde A, Amaral LAN, Havlin S, Fritsch-Yelle J, Baevsky RM, Stanley HE, Goldberger AL.
    Europhys Lett 1999;48:594-600. Citations: 110
  38. Is the normal heartbeat chaotic or homeostatic?
    Goldberger AL.
    News Physiol Sci. 1991 Apr;6:87-91. Citations: 109
  39. Hemodynamic and autonomic nervous system responses to mixed meal ingestion in healthy young and old subjects and patients with dysautonomic postprandial hypotension.
    Lipsitz LA, Ryan SM, Parker JA, Freeman R, Wei JY, Goldberger AL
    Circulation 1993;87:391-400. Citations: 105
  40. Dynamic analysis of heart rate may predict subsequent ventricular tachycardia after myocardial infarction
    Makikallio TH, Seppanen T, Airaksinen KE, Koistinen J, Tulppo MP, Peng CK, Goldberger AL, Huikuri HV.
    Am J Cardiol 1997;80:779-783. Citations: 103
  41. Fractal landscapes and molecular evolution: modeling the myosin heavy chain gene family.
    Buldyrev SV, Goldberger AL, Havlin S, Peng, CK, Stanley HE, Stanley MH, Simons M.
    Biophys J 1993;65:2673-2679. Citations: 101
  42. Volatility distribution in the S&P 500 Stock Index.
    Cizeau P, Liu Y, Meyer M, Peng CK, Stanley HE.
    Physica A 1997;245:441-445. Citations: 98
  43. Statistical mechanics in biology: how ubiquitous are long-range correlations?
    Stanley HE, Buldyrev SV, Goldberger AL, Goldberger ZD, Havlin S, Mantegna RN, Ossadnik SM, Peng CK, Simons M.
    Physica A. 1994 Apr 1;205(1-3):214-53. Citations: 93