Beth Israel Deaconess Medical Center MARGRET & H. A. REY
INSTITUTE
for Nonlinear Dynamics in Medicine 		Harvard Medical School
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Highly-Cited Articles

(Updated: June 29, 2009)
  1. Mosaic organization of DNA nucleotides.
    Peng CK, Buldyrev SV, Havlin S, Simons M, Stanley HE, Goldberger AL.
    Phys Rev E 1994;49:1685-1689. Citations: 826
  2. Quantification of scaling exponents and crossover phenomena in nonstationary heartbeat time series.
    Peng CK, Havlin S, Stanley HE, Goldberger AL.
    Chaos 1995;5:82-87. Citations: 757
  3. Long-range correlations in nucleotide sequences.
    Peng CK, Buldyrev SV, Goldberger AL, Havlin S, Sciortino F, Simons M, Stanley HE.
    Nature 1992;356:168-170. Citations: 611
  4. PhysioBank, PhysioToolkit, and PhysioNet: components of a new research resource.
    Goldberger AL, Amaral LA, Glass L, Hausdorff JM, Ivanov PC, Mark RG, Mietus JE, Moody GB, Peng CK, Stanley HE.
    Circulation 2000;101:E215. Citations: 435
  5. Multifractality in human heartbeat dynamics.
    Ivanov PCh, Amaral LAN, Goldberger AL, Havlin S, Rosenblum MG, Struzik Z, Stanley HE.
    Nature 1999;399:461-465. Citations: 428
  6. Long-range anticorrelations and non-Gaussian behavior of the heartbeat.
    Peng CK, Mietus J, Hausdorff JM, Havlin S, Stanley HE, Goldberger AL.
    Phys Rev Lett 1993;70:1343-1346. Citations: 406
  7. Spectral characteristics of heart rate variability before and during postural tilt - Relations to aging and risk of syncope.
    Lipsitz LA, Mietus JE, Moody GB, Goldberger AL.
    Circulation 1990;81:1803-1810. Citations: 362
  8. Physiological time-series analysis: What does regularity quantify?
    Pincus SM, Goldberger AL.
    Am J Physiol 1994;266:H1643-H1656. Citations: 346
  9. Statistical properties of the volatility of price fluctuations.
    Liu Y, Gopikrishnan P, Cizeau P, Meyer M, Peng CK, Stanley HE.
    Phys Rev E 1999;60:1390-400. Citations: 275
  10. Fractal dynamics in physiology: Alterations with disease and aging
    Goldberger AL, Amaral LAN, Hausdorff JM, Ivanov PC, Peng CK, Stanley HE
    PNAS USA 2002;99:2466-2472. Citations: 272
  11. Long-range correlation properties of coding and noncoding DNA sequences: GenBank analysis.
    Buldyrev SV, Goldberger AL, Havlin S, Mantegna RN, Matsa ME, Peng CK, Simons M, Stanley HE.
    Phys Rev E 1995;51:5084-5091. Citations: 256
  12. Loss of complexity and aging. Potential applications of fractals and chaos theory to senescence.
    Lipsitz LA, Goldberger AL.
    JAMA. 1992;267:1806-1809. Citations: 237
  13. Non-linear dynamics for clinicians: chaos theory, fractals, and complexity at the bedside.
    Goldberger AL.
    Lancet. 1996;347:1312-1314. Citations: 236
  14. Scaling behaviour of heartbeat intervals obtained by wavelet-based time series analysis.
    Ivanov PCh, Rosenblum MG, Peng CK, Mietus J, Havlin S, Stanley HE, Goldberger AL.
    Nature 1996;383:323-327. Citations: 222
  15. Aging and the complexity of cardiovascular dynamics.
    Kaplan DT, Furman MI, Pincus SM, Ryan SM, Lipsitz LA, Goldberger AL.
    Biophys J 1991;59:945-949. Citations: 197
  16. Fractal correlation properties of R-R interval dynamics and mortality in patients with depressed left ventricular function after an acute myocardial infarction.
    Huikuri HV, Makikallio TH, Peng CK, Goldberger AL, Hintze U, Moller M.
    Circulation 2000;101:47-53. Citations: 186
  17. Predicting survival in heart failure case and control subjects by use of fully automated methods for deriving nonlinear and conventional indices of heart rate dynamics.
    Ho KKL, Moody GB, Peng CK, Mietus JE, Larson MG, Levy D, Goldberger AL.
    Circulation 1997;96:842-848. Citations: 175
  18. Is walking a random walk? Evidence for long-range correlations in stride interval of human gait.
    Hausdorff JM, Peng CK, Ladin Z, Wei JY, Goldberger AL.
    J Appl Physiol 1995;78:349-358. Citations: 170
  19. Age-related alterations in the fractal scaling of cardiac interbeat interval dynamics.
    Iyengar N, Peng CK, Morin R, Goldberger AL, Lipsitz LA.
    Am J Physiol 1996;271:R1078-R1084. Citations: 163
  20. Linguistic features of noncoding DNA sequences.
    Mantegna RN, Buldyrev SV, Goldberger AL, Havlin S, Peng CK, Simons M, Stanley HE.
    Phys Lett Rev 1994;73:3169-3172. Citations: 155
  21. Gender-related and age-related differences in heart rate dynamics: are women more complex than men?
    Ryan SM, Goldberger AL, Pincus SM, Mietus JE, Lipsitz LA.
    J Am Coll Cardiol 1994;24:1700-1707. Citations: 154
  22. Altered fractal dynamics of gait: reduced stride interval correlations with aging and Huntington's disease.
    Hausdorff JM, Mitchell SL, Firtion R, Peng CK, Cudkowicz ME, Wei JY, Goldberger AL.
    J Appl Physiol 1997;82:262-269. Citations: 145
  23. Magnitude and sign correlations in heartbeat fluctuations.
    Ashkenazy Y, Ivanov PCh, Havlin S, Peng CK, Goldberger AL, Stanley HE.
    Phys Rev Lett 2001;86:1900-1903. Citations: 141
  24. Cardiac interbeat interval dynamics from childhood to senescence: comparison of conventional and new measures based on fractals and chaos theory.
    Pikkujämsä SM, Mäkikallio TH, Sourander LB, Räihä IJ, Puukka P, Skyttä J, Peng CK, Goldberger AL, Huikuri HV.
    Circulation 1999;100:393-399. Citations: 136
  25. Gait variability and basal ganglia disorders: Stride-to-stride variations of gait cycle timing in Parkinson's disease and Huntington's disease
    Hausdorff JM, Cudkowicz ME, Firtion R, Wei JY, Goldberger AL.
    Movement Disorders, 13:428-437 May 1998. Citations: 130
  26. Fractal dynamics of human gait: Stability of long-range correlations in stride interval fluctuations
    Hausdorff JM, Purdon PL, Peng CK, Ladin Z, Wei JY, Goldberger AL.
    J Appl Physiol 1996;80:1448-1457. Citations: 119
  27. Correlations in economic time series
    Liu Y, Cizeau P, Meyer M, Peng CK, Stanley HE.
    Physica A 1997;245:437-440. Citations: 115
  28. Finite size effects on longrange correlations: implications for analyzing DNA sequences
    Peng CK, Buldyrev SV, Goldberger AL, Havlin S, Simons M, Stanley HE.
    Phys Rev E 1993;47:3730-3733. Citations: 109
  29. Multiscale entropy analysis of complex physiologic time series
    Costa M, Goldberger AL, Peng CK
    Phys Rev Lett 2002;89:068102. Citations: 107
  30. Behavioral-independence features of complex heartbeat dynamics
    Amaral LAN, Ivanov PCh, Aoyagi N, Hidaka I, Tomono S, Goldberger AL, Stanley HE, Yamamoto Y.
    Phys Rev Lett 2001;86:6026-6029. Citations: 105
  31. Fractal analysis of heart rate dynamics as a predictor of mortality in patients with depressed left ventricular function after acute myocardial infarction
    Makikallio TH, Hoiber S, Kober L, Torp-Pedersen C, Peng CK, Goldberger AL, Huikuri HV
    Am J Cardiol 1999;83:836-839. Citations: 100
  32. Hemodynamic and autonomic nervous system responses to mixed meal ingestion in healthy young and old subjects and patients with dysautonomic postprandial hypotension.
    Lipsitz LA, Ryan SM, Parker JA, Freeman R, Wei JY, Goldberger AL
    Circulation 1993;87:391-400. Citations: 100
  33. Generalized Levy walk model for DNA nucleotide sequences.
    Buldyrev SV, Goldberger AL, Havlin S, Peng CK, Simons M, Stanley HE.
    Phys Rev E 1993;47:4514-4523. Citations: 98
  34. Is the normal heartbeat chaotic or homeostatic?
    Goldberger AL.
    News Physiol Sci. 1991 Apr;6:87-91. Citations: 98
  35. Statistical physics and physiology: Monofractal and multifractal approaches
    Stanley He, Amaral LA, Goldberger AL, Havlin,S, Ivanov PCh, Peng CK.
    Physica A. 1999;270:309-24. Citations: 96
  36. From 1/f noise to multifractal cascades in heartbeat dynamics.
    Ivanov PC, Nunes Amaral LA, Goldberger AL, Havlin S, Rosenblum MG, Stanley HE, Struzik ZR.
    Chaos. 2001 Sep;11(3):641-652. Citations: 93
  37. Fractal landscapes and molecular evolution: modeling the myosin heavy chain gene family.
    Buldyrev SV, Goldberger AL, Havlin S, Peng, CK, Stanley HE, Stanley MH, Simons M.
    Biophys J 1993;65:2673-2679. Citations: 93
  38. Sleep-wake differences in scaling behavior of the human heartbeat: Analysis of terrestrial and long-term space flight data
    Ivanov PCh, Bunde A, Amaral LAN, Havlin S, Fritsch-Yelle J, Baevsky RM, Stanley HE, Goldberger AL.
    Europhys Lett 1999;48:594-600. Citations: 88
  39. Dynamic analysis of heart rate may predict subsequent ventricular tachycardia after myocardial infarction
    Makikallio TH, Seppanen T, Airaksinen KE, Koistinen J, Tulppo MP, Peng CK, Goldberger AL, Huikuri HV.
    Am J Cardiol 1997;80:779-783. Citations: 87
  40. Statistical mechanics in biology: how ubiquitous are long-range correlations?
    Stanley HE, Buldyrev SV, Goldberger AL, Goldberger ZD, Havlin S, Mantegna RN, Ossadnik SM, Peng CK, Simons M.
    Physica A. 1994 Apr 1;205(1-3):214-53. Citations: 85